Dr. Stram's research interests center on the development and application of modern statistical methods. He is especially interested in measurement error methods in cancer epidemiology, methods for the analysis of repeated measures data, and human genetics data. He has worked extensively on these issues in the A-bomb survivor cohort and other important data series. He is also involved in the conduct of clinical trials through the Childrens Cancer Group.
Description:I am an experienced statistician with many interests and publications in areas relevant to cancer epidemiology including: general biostatistical methods in survival analysis, longitudinal analysis, meta-analysis, and measurement error; experimental design of genotyping studies and calibration studies; analysis of genetic association studies including haplotype analysis and most recently in problems related to hidden population stratification and cryptic relatedness. I am the senior statistician on a large number of genome-wide association studies including those at USC centered around the Multiethnic Cohort Study. I serve as chair of the statistics working group for the Breast and Prostate Cancer cohort consortium and am directing the statistical analysis for a Singapore-based diabetes GWAS. I have longstanding research interests in radiation epidemiology and related statistical issues, starting from my work performed in the late 1980s in Hiroshima for the A-bomb study. I am currently chair of the US EPA's Radiation Advisory Committee, and serve on the US-EPA's Scientific Advisory Board
- Development and application of modern statistical methods
- Masurement error methods in cancer epidemiology, methods for the analysis of repeated measures data, and human genetics data
HISTORY & EDUCATION
- Temple University, Ph.D., 1983
- Harvard School of Public Health, MPH, 1986
- Tufts University, B.A., 1975
- Postdoctoral Fellow, Biostatistics Department, Harvard School of Public Health, Boston, MA., 1984 – 1986
- Statistician, Center for Energy and Environmental Studies Princeton University, Princeton NJ., 1982 – 1984
- Research Associate, Radiation Effects Research Foundation Hiroshima, Japan., 1986 – 1989
- Assistant Professor, Dept of Preventive Medicine, University of Southern California, Los Angeles, CA., 1989 – 1996
MEMBERSHIPS & AFFILIATIONS
- Elected Fellow of the American Statistical Association, 2009
- American Statistical Association
- Stram DO. Meta-analysis of published data using a linear mixed-effects model. Biometrics 52:108-115, 1996.
- Thomas DC, Stram DO, Dweyer J. Exposure Measurement Error: Influence on exposure-disease relationships and methods of correction. Annals of Public Health, 14:69-93, 1993.
- Stram DO, Lee JW. Variance components testing in the longitudinal mixed-effects model. Biometrics, 50:1171-1177, 1994.
- Stram DO, Longnecker MP, Shames L, Kolonel LN, Wilkens LR, Pike MC, Henderson BE. Cost efficient design of a diet validation study. American Journal of Epidemiology, 142:353-362, 1995.
- Stram DO, Langholz B, Huberman M, Thomas DC. Correcting for exposure measurement error in a reanalysis of lung cancer mortality for the Colorado Plateau uranium miners cohort. Health Physics 77:265-275, 1999.
- Stram DO, Hankins JH, Wilkens LR, Pike MC, Monroe KR, Park S, Henderson BE, Nomura AMY, Earle ME, Nagamine FS, Kolonel LN. Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles. American Journal of Epidemiology, 151:358-370, 2000.
- Stram DO, Huberman J, Wu AH. Is residual confounding a reasonable explanation for the apparent protective effects of beta-carotene found in epidemiologic studies of lung cancer in smokers? Am J Epidemiol 155: 622-628, 2002.
- Stram DO, Haiman CA, Hirschhorn JN, Altshuler D, Kolonel LN, Henderson BE, Pike MC. Choosing Haplotype-tagging SNPs based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study, Human Heredity 55:27-36, 2003.
- Stram DO, Pearce CL, Bretsky P, Freedman M, Hirschhorn JN, Altshuler D, Kolonel LN, Henderson BE, Thomas DC. Modeling and E-M Estimation of Haplotype-Specific Relative Risks from Genotype Data for a Case-Control Study of Unrelated Individuals, Human Heredity, 55:179-190, 2003.
- Haiman CA, Stram DO, Wilkens LR, Pike MC, Kolonel LN, Henderson BC, Le Marchand L Ethnic and racial differences in smoking-related lung cancer risk: The Multiethnic Cohort NEJM, 354:333-42, 2006
- Wang H, Thomas DC, Pe’er I, Stram DO, Optimal two-stage genotyping designs for genome-wide association scans. Genetic Epidemiology, 30:356-368, 2006
- Kraft P, Stram DO, The use of Inferred Haplotypes in Downstream Analysis, American Journal of Human Genetics, 81:863-5, 2007
- Rakovski CS, Stram DO. A kinship-based modification of the Armitage trend test to address hidden population structure and small differential genotyping errors. PLoS One 4:e5825, 2009. PMC2688076
- Chen GK, Millikan RC, John EM, Ambrosone CB, Bernstein L, Stram DO (2010) Enhancing the Power of Genetic Association Studies Through The Use of Publicly Available Genotype Data. PLoS Genetics e1001096, 2010. PMC2932740
- Stram DO, Liu Y, Henderson KD, Sullivan-Halley J, Luo J, Saxena T, Reynolds P, Chang E T, Neuhausen S L, Horn-Ross PL, Bernstein L, and Ursin G Age-specific effects of hormone therapy use on overall mortality and ischemic heart disease mortality among women in the California Teachers Study. Menopause 18:153-261, 2011.
Direct link to profile: http://keck.usc.edu/profiles?facid=1141